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December 8, 2025BloodOpen Access

Burden and trends of sickle cell disease in the United States: Insights from the global burden of disease study 2021

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Authors

SMSameer Kumar MajetyMHMegha Sasidhar HandralRNRithish Nimmagadda

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Overview

Analysis reveals declines in sickle cell disease prevalence and mortality in infants and other age groups, suggesting need for improved health literacy and interventions.

Key Points

  • To quantify the burden of sickle cell disease (SCD) across the U.S. and evaluate trends over time.
  • Utilized Global Burden of Disease dataset from IHME 2021.
  • Analyzed age-standardized rates of prevalence, mortality, and disability-adjusted life years (DALYs) by state and sex.
  • Calculated Estimated Annual Percentage Change (EAPC) for each outcome.
  • Identified high-burden subgroups with age-specific mortality and DALY statistics.
  • Performed descriptive statistics focusing on demographic and geographic variations.
  • Prevalence rate showed a declining trend with an EAPC of -0.64%.
  • Age-standardized death rate declined with an EAPC of -0.82%.
  • DALY rate decreased with an EAPC of -1.06%, indicating improvement in disease-related outcomes.
  • SCD burden was highest in southern and mid-Atlantic states, with significant female predominance overall.
  • Early life outcomes showed high incidence and mortality among infants and neonates.

Cite This Study

Majety et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d53dhttps://doi.org/10.1182/blood-2025-6227
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Also Consider

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  1. 1Sickle cell disease in the global south: Mapping the unmet burden using global burden of disease DALY estimates and its relevance to United States hematologists2025
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  3. 3Paradoxical urban mortality penalty in sickle cell disease: A 20-year national analysis revealing age-dependent disparities2025
  4. 4Trends in the burden of sickle cell disorders in Sierra Leone, 1990–2023: An analysis of Global Burden of Disease Study 2023 estimates2026
  5. 5Birth Prevalence of Sickle Cell Disease and County-Level Social Vulnerability — Sickle Cell Data Collection Program, 11 States, 2016–20202024 · 41 citations