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This research aims to assess the impact of induction therapy on immune aging in multiple myeloma patients.

December 8, 2025Blood

Accelerated immune aging after induction therapy in multiple myeloma revealed by donor-referenced immune age modeling

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This research aims to assess the impact of induction therapy on immune aging in multiple myeloma patients.
Analyzed peripheral blood flow cytometry data from 219 MM patients and 150 healthy donors.
Utilized a 10-color panel for differentiating T cells and B cells.
Estimated immune age gaps through spline inversion of donor-derived splines.
MM patients showed statistically significant accelerated decline in CD4⁺ naïve T cells compared to healthy donors.
Median immune-age gaps of approximately 15 to 18 years were observed across markers.
Younger MM patients displayed immune phenotypes resembling older healthy donors, indicating accelerated immune aging.

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Findings show immune aging impacts immunogenicity in multiple myeloma post-induction therapy, suggesting new strategies may improve outcomes.

Malek et al. (2025) studied this question.

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Findings show immune aging impacts immunogenicity in multiple myeloma post-induction therapy, suggesting new strategies may improve outcomes.