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December 8, 2025BloodOpen Access

Bzip in-frame mutations might abrogate the adverse prognosis of therapy-related CEBPA-mutated AML

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Authors

GCGuanghui ChangHGHaitao GaoXZXiao‐Su Zhao

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Overview

This study finds similar characteristics and poor prognosis for therapy-related CEBPA AML and t-AML, indicating risks of relapse and the role of allo-HSCT.

Key Points

  • To investigate the clinical characteristics and prognosis of therapy-related CEBPA-mutated AML.
  • Compared genetic characteristics and outcomes between t-CEBPA AML, dn-CEBPA AML, and therapy-related AML with wild type CEBPA.
  • Analyzed clinical data of 478 patients from a hematology institute from January 2017 to December 2024.
  • Assessed the impact of allogeneic hematopoietic stem cell transplantation on patient survival.
  • T-CEBPA AML and t-AML had similar co-mutation profiles and older patient age compared to dn-CEBPA AML.
  • Higher relapse rates observed in t-CEBPA AML and t-AML than in dn-CEBPA AML.
  • Allo-HSCT improved overall survival for t-CEBPA AML and t-AML, but not for dn-CEBPA AML.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d68dhttps://doi.org/10.1182/blood-2025-5163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced prognosis of acute myeloid leukaemia patients with dm CEBPA bZIP ‐inf mutations: Insights from a multicentre Chinese cohort study2026
  2. 2Characteristics and outcomes of CEBPA bZIP in-frame mutations in de novo and treated secondary acute myeloid leukemia2025
  3. 3CCAAT/enhancer‐binding protein alpha basic leucine zipper in‐frame insertion/deletion ( <scp> <i>CEBPA</i> bZIP </scp> ‐ <scp>InDel</scp> ‐inf) defines a favourable‐prognosis subgroup in <scp> <i>CEBPA</i> </scp> ‐mutated acute myeloid leukaemia2026
  4. 4Clinical and Prognostic Significance of CEBPA Mutations in Myelodysplastic Syndromes2026
  5. 5Clinical outcomes and molecular features of CEBPA-mutated MPAL: a multi-center case series2026