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December 8, 2025BloodOpen Access

Outcomes of patients with light-chain amyloidosis after heart transplantation: A single center cohort.

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Authors

JPJosé Miguel Mateos PérezJOJosè T. Ortiz-PérezLDLaura Rosiñol Dachs

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Overview

Cohort analysis shows heart transplantation improves progression-free survival in light chain amyloidosis patients, suggesting key therapeutic strategies.

Key Points

  • To analyze outcomes in patients with light chain amyloidosis after heart transplantation.
  • Retrospective cohort analysis of patients with light chain amyloidosis who underwent heart transplantation (HT).
  • Data collection included patients' characteristics, treatment regimens, and survival outcomes.
  • Follow-up data included hematologic responses and cardiac function post-HT.
  • Ten patients received heart transplantation; most had advanced cardiac involvement.
  • Ninety percent achieved a hematologic response, with significant improvements in left ventricular ejection fraction post-HT.
  • Median overall survival was 116.5 months, indicating significant survival advantage post-transplant.

Cite This Study

Pérez et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6b6https://doi.org/10.1182/blood-2025-7494
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