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This research aims to investigate the role of IL-39 in the pathogenesis of acute graft-versus-host disease (aGVHD).

December 8, 2025Blood

IL-39/IL-39R signaling drives acute graft-versus-host disease

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This research aims to investigate the role of IL-39 in the pathogenesis of acute graft-versus-host disease (aGVHD).
Measured IL-39 levels in patients pre and post hematopoietic cell transplantation using ELISA during a clinical study.
Analyzed IL-39 associations with clinical outcomes via linear mixed models and Cox regression.
Assessed effects of human recombinant IL-39 on T cell responses in both murine and human models.
Higher plasma IL-39 levels were linked to greater severity of aGVHD and increased non-relapse mortality.
hrIL-39 stimulated T cell proliferation and inflammatory cytokine production, exacerbating aGVHD in murine models.
IL-39 signaling was confirmed to require IL-23Rα for its pathogenic effects in both human and murine cells.

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Findings demonstrate elevated IL-39 levels correlate with aGVHD severity and non-relapse mortality, indicating potential biomarker for therapy.

Pugel et al. (2025) studied this question.

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Findings demonstrate elevated IL-39 levels correlate with aGVHD severity and non-relapse mortality, indicating potential biomarker for therapy.