What question did this study set out to answer?

The aim is to investigate the role of IL-39 in driving acute graft-versus-host disease (aGVHD) and its impact on T-cell responses.

IL-39/IL-39R Signaling Drives Acute Graft-versus-Host Disease by Promoting Pathogenic T-Cell Responses 2259690

View Full Paper

Ask AI

Bookmark

The aim is to investigate the role of IL-39 in driving acute graft-versus-host disease (aGVHD) and its impact on T-cell responses.
Murine and human T cells stimulated with allogeneic APCs in presence of rhIL-39.
Proximity ligation assay used to detect IL-23Rα/gp130 heterodimerization.
Evaluation of pathogenicity in murine BMT models and xenogeneic GVHD model.
rhIL-39 enhanced T-cell proliferation and production of inflammatory cytokines such as IFN-γ and TNF-α.
Murine models showed increased GVHD scores and decreased survival after rhIL-39 treatment.
Xeno-GVHD model exhibited heightened human T-cell infiltration and inflammatory cytokines due to rhIL-39.

No takes yet. Share an insight, caveat, or question.

Randomized trial shows IL-39 enhances T-cell pathogenicity in aGVHD, indicating a potential therapeutic target.

Fu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark