What type of study is this?

This is a Systematic Review study.

What question did this study set out to answer?

To assess patient-reported outcomes in Phase 3 trials for multiple myeloma published between 2020 and 2024.

December 8, 2025BloodOpen Access

Assessing patient-reported outcomes in Phase 3 multiple myeloma trials between 2020-2024 – a systematic review.

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Authors

NANawaraj AdhikariStaten Island University Hospital UBUjwal BasnetStaten Island University Hospital

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Implication

Systematic review evaluates quality of life and patient-reported outcomes in clinical trials for multiple myeloma, highlighting inconsistent reporting.

Key Points

To assess patient-reported outcomes in Phase 3 trials for multiple myeloma published between 2020 and 2024.
Conducted a literature search in PubMed, Cochrane, and Embase for Phase 3 clinical trials from 2020 to 2024.
Evaluated if trials included patient-reported outcomes as a main or supplementary report.
Analyzed the statistical significance of PRO between intervention and control arms.
Out of 5226 articles, 21 studies met the inclusion criteria for this review.
Fifteen trials (71%) reported patient-reported outcomes; 14 included them in the main text.
Most trials (14/15) listed PRO as a secondary endpoint, indicating heterogeneity in PRO measures used.

Cite This Study

Adhikari et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7e1 https://doi.org/10.1182/blood-2025-2822

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Implication

Systematic review evaluates quality of life and patient-reported outcomes in clinical trials for multiple myeloma, highlighting inconsistent reporting.

Assessing patient-reported outcomes in Phase 3 multiple myeloma trials between 2020-2024 – a systematic review.

Discussion

Member takes

Implication

Key Points

Cite This Study

Assessing patient-reported outcomes in Phase 3 multiple myeloma trials between 2020-2024 – a systematic review.

Discussion

Member takes

Implication

Key Points

Cite This Study

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