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December 8, 2025BloodOpen Access

Short-term and long-term sting activation elicit divergent cellular responses in distinct hematopoietic populations in chronic myelomonocytic leukemia

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Authors

YWYue WeiZLZiyi LiKLK. J. Linthicum

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Overview

Experimental evaluation reveals STING activation induces apoptosis and alters gene expression in hematopoietic cells from CMML patients, suggesting therapeutic potential.

Key Points

  • This research examines how STING activation affects different hematopoietic populations in chronic myelomonocytic leukemia (CMML).
  • Evaluated STING activation effects in hematopoietic stem-cells and monocytes from CMML patients and healthy donors.
  • Utilized STING agonist dazostinag and TAK-500 in co-cultures with mesenchymal stromal cells.
  • Conducted single-cell RNA sequencing (scRNA-seq) to analyze gene expression dynamics and cell interactions.
  • STING activation led to dose-dependent apoptosis in monocytes and altered gene expression in CMML hematopoietic cells.
  • Short-term STING activation depleted CCR2+ monocytes and affected colony-forming capabilities in hematopoietic progenitors.
  • Long-term STING activation did not yield similar effects, indicating adaptive cellular responses.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d83bhttps://doi.org/10.1182/blood-2025-3832
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1INVESTIGATING THE ROLE OF STING SIGNALLING IN IMMUNE AND NON-IMMUNE CELLULAR COMPARTMENTS ON SURVIVAL PHENOTYPES IN THE KP MODEL OF UNDIFFERENTIATED PLEOMORPHIC SARCOMA2026
  2. 2DIFFERENTIAL STING ACTIVATION IN DENDRITIC CELLS SHAPES DISTINCT CD4 T CELL RESPONSES AND OPPOSING COLITIS OUTCOMES2026
  3. 3Abstract 6734: Preclinical impact of pretreatment with CRS mitigation agents on pharmacodynamic response to TAK-500, a systemically delivered CCR2-targeted STING agonist iADC2024
  4. 4ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia2025
  5. 5Loss of serine threonine protein kinase 25 (STK25) in the bone marrow niche attenuates g/CSF- and TLR7-induced emergency myelopoiesis and mobilization into the periphery2025