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December 8, 2025Parasitology ResearchOpen Access

Effect of antiserum against recombinant EGr₀9888 on the in vitro development of Echinococcus granulosus protoscoleces

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Authors

WKWulijiang KamaliWBWan-Li BanYMYongping Mu

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Overview

In vitro treatment with anti-EGr_09888 serum reduced survival and expression of EGr_09888 in protoscoleces, indicating vaccine potential.

Key Points

  • To investigate the role of the EGr_09888 protein in the development of Echinococcus granulosus protoscoleces in vitro.
  • Developed a recombinant plasmid for protein expression and purification.
  • Immunized rabbits to produce high-titer anti-EGr_09888 serum.
  • Analyzed gene expression and survival rates in cultured protoscoleces after treatment with the serum.
  • Utilized immunofluorescence staining to examine protein localization.
  • Anti-EGr_09888 serum significantly reduced survival rate of protoscoleces after treatment.
  • Gene expression of EGr_09888 in treated protoscoleces was significantly lower.
  • The EGr_09888 protein showed immunogenic potential with identified B- and T-cell epitopes.

Cite This Study

Kamali et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d89dhttps://doi.org/10.1007/s00436-025-08604-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Characterization and Functional Effect on Canine Peripheral Blood Mononuclear Cells of an Uncharacterized Major Egg Antigen EGR-01664 from Echinococcus granulosus2025
  2. 2Molecular characterization of Echinococcus granulosus EGR-02244 and its functional role in canine peripheral blood mononuclear cells.2026
  3. 3Molecular characterization and functional effect on canie peripheral blood mononuclear cells of phosphoglycerate kinase from Echinococcus granulosus2026
  4. 4Immunogenicity and protective efficacy of the novel candidate antigen Eg174 against Echinococcus granulosus infection in a murine model2026
  5. 5Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates2025