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December 8, 2025Blood

Comparison of autologous HCT versus haploidentical donor HCT for Ph+ B-ALL patients following TKI therapy. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation

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Authors

YRYuhua RuDWDepei WuMBMalek Benakli

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Overview

Multicenter comparison shows similar leukemia-free survival but lower relapse in haploidentical HCT for Ph+ B-ALL patients post-TKI.

Key Points

  • To compare outcomes of autologous HCT and haploidentical HCT in Ph+ B-ALL patients after TKI therapy.
  • Retrospective analysis of EBMT registry data from Ph+ B-ALL patients in first remission (2010-2022)
  • Cohorts matched by minimal residual disease status and other factors using a 2:1 matching algorithm
  • Data on transplant outcomes including survival and relapse rates were collected.
  • 434 patients analyzed: 117 auto-HCT and 317 haplo-HCT recipients
  • Haplo-HCT associated with lower relapse incidence (10.3% vs. 28%) but higher non-relapse mortality (14.8% vs. 2.1%)
  • Both groups had similar leukemia-free survival outcomes (69.9% vs. 75%) over 3 years.

Cite This Study

Ru et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8b3https://doi.org/10.1182/blood-2025-6080
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparable outcomes of haploidentical, sibling, and unrelated donor transplantation for adult T-ALL in second remission: a study from the global committee and ALWP of the EBMT2025
  2. 2Comparison of outcomes in pediatric patients with acute leukemia undergoing allogeneic HLA-haploidentical hematopoietic stem cell transplantation (HSCT) after in vitro a/b T- and CD19-cell depletion or In Vivo administration of post-transplant cyclophosphamide: An EBMT pediatric working party study2025
  3. 3Allogeneic hematopoietic cell transplantation following chimeric antigen receptor T-cell (CAR-T) therapy in B-cell acute lymphoblastic leukemia (B-ALL): A systematic review and meta-analysis.2026
  4. 4Autologous stem cell transplantation versus consolidation chemotherapy as post-remission treatment in newly diagnosed favorable and intermediate risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials2025
  5. 5A comparison of haploidentical versus HLA-identical sibling outpatient hematopoietic cell transplantation using reduced intensity conditioning in patients with acute leukemia2024 · 5 citations