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December 8, 2025BloodOpen Access

Impact of episodes of acute chest syndrom on the cardiac remodeling in children and young adults with sicle cell disease.

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Authors

SJSylvain Le JeuneAMAntonino MorabitoNBNabil Belaid

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Overview

Longitudinal study assesses acute chest syndrome effects on cardiac remodeling and pulmonary hypertension in children and young adults.

Key Points

  • To investigate how episodes of acute chest syndrome affect cardiac remodeling and pulmonary hypertension in children and young adults with sickle cell disease.
  • Conducted a longitudinal multicenter study
  • Included 400 children and young adults with sickle cell disease under 25 years
  • Collected death cases from health hospital records
  • Primary outcome measured was pulmonary artery pressure using echocardiographic techniques
  • Analyzed frequency of acute chest syndrome episodes and their correlation with cardiac complications.
  • 52 individuals with sickle cell disease enrolled from 2 referral centers
  • Mean age was 17.1 years with a sex ratio of 0.5
  • Cardiac mortality reported in 4 cases, 3 due to acute chest syndrome
  • Patients with acute chest syndrome did not show early diastolic dysfunction compared to those without.
  • No child had TRV above 2.5 m/sec or e' lateral below 11 cm/sec.

Cite This Study

Jeune et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9afhttps://doi.org/10.1182/blood-2025-2972
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Remodeling Patterns in Pediatric and Adolescent Patients with Sickle Cell Disease and Their Association with the Genotype and Clinical Severity of the Disease: A Systematic Review2026
  2. 2Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations
  3. 3195 Echocardiographic evaluation in children with sickle cell anemia2024
  4. 4C65-12 Clinical and Laboratory Findings in Adults With Sickle Cell Disease Which Increase Risk for Severe Acute Chest Syndrome2026
  5. 5Predictors of Acute Chest Syndrome Following Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease2026 · 1 citations