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December 8, 2025BloodOpen Access

Echocardiographic findings over time in sickle cell disease patients: A single-center study

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To analyze echocardiographic findings over time in sickle cell disease patients receiving different therapies.
Retrospective study of 36 sickle cell disease patients
Categorized patients into therapy groups: disease-modifying drugs vs. no therapy
Analyzed echocardiogram findings including TR velocity and LVEF
Patients on Hydroxyurea had an increase in TR velocity (0.05 m/s) and LVEF (4%)
Those not on therapy showed a 20% increase in moderate to severe heart chamber dilation
Echocardiogram findings varied between those on and not on disease-modifying drugs.

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Retrospective analysis reveals echocardiogram changes in sickle cell disease patients, indicating treatment impacts cardiac function.

Modupe Idowu (2025) studied this question.

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