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December 8, 2025Blood

Therapy-related AML (t-AML) on the rise: A national perspective on evolving trends, treatment outcomes, and prognostic implications in hospitalized patients

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Authors

PSPrakhyath Srikaram

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Overview

Retrospective analysis shows t-AML patients have lower inpatient mortality and complications, indicating improved treatment strategies.

Key Points

  • To evaluate trends and outcomes for therapy-related Acute Myeloid Leukemia in hospitalized patients.
  • Retrospective cohort study using the National Inpatient Sample from 2016 to 2021
  • Analyzed differences in clinical outcomes for t-AML versus de novo AML
  • Used ICD-10 codes to identify hospitalizations for AML
  • Applied multivariable logistic and linear regression models to assess associations
  • t-AML hospitalizations decreased from 0.37% in 2016 to 0.34% in 2021
  • In-hospital mortality for t-AML decreased from 6.1% to 4.5%
  • t-AML associated with shorter length of stay by 1.25 days and lower hospital charges by approximately $40,516
  • Lower odds of in-hospital mortality, sepsis, and acute kidney injury for t-AML compared to de novo AML

Cite This Study

Prakhyath Srikaram (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da04https://doi.org/10.1182/blood-2025-5181
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy2024 · 12 citations
  2. 2Therapy-related core binding factor Acute Myeloid Leukemia – a Study of the french acute leukemia intergroup2025
  3. 3Inpatient outcomes in acute myeloid leukemia: A contemporary national study.2026
  4. 4National analysis of real-world racial and ethnic disparities in mortality, complications, and healthcare costs among adults hospitalized with newly diagnosed Acute Myeloid Leukemia2025
  5. 5Trends on treatment patterns in patients with newly diagnosed AML: Preliminary findings from a real-world analysis.2024