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December 8, 2025BloodOpen Access

Limited diagnostic utility of abdominal fat pad biopsy for systemic amyloidosis: A single institution's experience

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Retrospective review of abdominal fat pad biopsy reveals 9% sensitivity for systemic amyloidosis, highlighting the need for standardized procedures.

To assess the diagnostic utility of abdominal fat pad biopsy for systemic amyloidosis based on institutional experience.
Conducted a retrospective review of abdominal fat pad biopsies over 27 months at a 500-bed academic hospital.
Analyzed biopsy results, clinical outcomes, and follow-up for patients.
Evaluated tissue volume of biopsy cores and performed quality control with Congo Red staining.
Of 48 biopsies, 46 (96%) were negative for amyloid, revealing a sensitivity of only 9%.
Among negative biopsies, 10 (22%) had amyloid confirmed in subsequent targeted organ biopsies.
Cardiac amyloidosis evaluations had a higher likelihood of false negatives compared to neuropathy cases.

Oliver et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Retrospective review of abdominal fat pad biopsy reveals 9% sensitivity for systemic amyloidosis, highlighting the need for standardized procedures.

To assess the diagnostic utility of abdominal fat pad biopsy for systemic amyloidosis based on institutional experience.
Conducted a retrospective review of abdominal fat pad biopsies over 27 months at a 500-bed academic hospital.
Analyzed biopsy results, clinical outcomes, and follow-up for patients.
Evaluated tissue volume of biopsy cores and performed quality control with Congo Red staining.
Of 48 biopsies, 46 (96%) were negative for amyloid, revealing a sensitivity of only 9%.
Among negative biopsies, 10 (22%) had amyloid confirmed in subsequent targeted organ biopsies.
Cardiac amyloidosis evaluations had a higher likelihood of false negatives compared to neuropathy cases.

Oliver et al. (2025) studied this question.

View Full Paper

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Bookmark