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December 8, 2025Blood

Diagnostic challenges in systemic light chain( AL) amyloidosis: A retrospective evaluation of biopsy yeild and typing strategies in an Indian tertiary care centre

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Authors

NSNeeraj SidharthanAHAparna HariGGGeorg Gutjahr

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Overview

Retrospective analysis reveals diagnostic sensitivity of biopsy techniques for AL amyloidosis in an Indian cohort, indicating challenges in mass spectrometry access.

Key Points

  • To evaluate biopsy strategies and their diagnostic yield in patients suspected of having AL amyloidosis.
  • Conducted a retrospective study from 2002 to mid-2024
  • Included patients with biopsy-confirmed amyloid deposition
  • Categorized patients based on predominant organ involvement
  • Assessed outcomes through clinical and histologic records
  • Calculated diagnostic sensitivity by biopsy site
  • Identified amyloid deposition in 74% of biopsy patients
  • Target organ biopsies had 74% sensitivity; surrogate sites at 40%
  • Biopsy-negative cases included 49% with single-site biopsy
  • Mass spectrometry typing performed in only 14% of positive cases
  • Echocardiography revealed diastolic dysfunction in cardiac involvement cases

Cite This Study

Sidharthan et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfe2https://doi.org/10.1182/blood-2025-8140
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Presenting features, treatment patterns and predictors of outcomes in AL amyloidosis at a tertirary care cancer centre2025
  2. 2Diagnostic Accuracy of Fat Pad Sampling and Bone Marrow Biopsy for AL Amyloidosis: A Systematic Review and Meta-Analysis2026
  3. 3Diagnostic Challenges in Amyloid Light-Chain Amyloidosis2026
  4. 4Limited diagnostic utility of abdominal fat pad biopsy for systemic amyloidosis: A single institution's experience2025
  5. 5EXPLORING AA AMYLOIDOSIS: INSIGHTS FROM A CASE SERIES IN AN UNDER-EXPLORED INDIAN CONTEXT2024