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December 8, 2025Blood

Impact of antibiotic exposure on CAR-T cell therapy outcomes: Analysis in multiple Myeloma and lymphoma

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Authors

YWYing WangHenan University Huaihe Hospital and Huaihe Clinical InstituteZLZhenyu LiHebei Medical UniversityKXKailin XuHebei Medical University

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Implication

Retrospective analysis reveals antibiotic exposure reduces treatment outcomes and progression-free survival in lymphoma patients, indicating concerns for CAR-T therapy efficacy.

Key Points

  • To assess the impact of pre-CAR-T antibiotic exposure on treatment outcomes in multiple myeloma and lymphoma patients.
  • Retrospective analysis of CAR-T therapy cohorts in multiple myeloma and lymphoma.
  • Grouped patients based on antibiotic exposure within 4 weeks prior to CAR-T infusion.
  • Compared outcomes such as overall survival and progression-free survival between antibiotic-exposed and non-exposed groups.
  • In multiple myeloma, complete remission rates were significantly lower in the antibiotic-exposed group.
  • Antibiotic exposure was associated with shorter median progression-free survival and overall survival in lymphoma patients.
  • No significant differences were observed in cytokine release syndrome incidences between exposed and non-exposed groups.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da8ahttps://doi.org/10.1182/blood-2025-4071
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibiotic Use Before CAR-T Treatment Is Associated with Inferior Outcomes in DLBCL Lymphoma Patients.2026
  2. 2Antibiotic Use Before CAR-T Treatment Is Associated with Inferior Outcomes in DLBCL Lymphoma Patients2026 · 2 citations
  3. 3Abstract 6672: Unraveling the microbiome: antibiotic impact on CAR T therapy and the synergistic potential of vancomycin in enhancing antitumor immunity2024 · 1 citations
  4. 4Longitudinal metagenomic profiling of gut microbiome dynamics in B-cell lymphoma patients receiving CAR-T cell therapy2026
  5. 5Impact of broad-spectrum antibiotic exposure on outcomes following autologous stem cell transplantation for patients with relapsed diffuse large B-cell lymphoma or Hodgkin lymphoma2025