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December 8, 2025BloodOpen Access

Impact of broad-spectrum antibiotic exposure on outcomes following autologous stem cell transplantation for patients with relapsed diffuse large B-cell lymphoma or Hodgkin lymphoma

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Authors

MAM. AndersonNebraska Medical CenterSASnegha AnanthNebraska Medical CenterJVJulie VoseNebraska Medical Center

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Implication

Retrospective analysis reveals antibiotic exposure impacts survival outcomes in lymphoma patients post-transplant, suggesting clinical implications.

Key Points

  • To ascertain the impact of broad-spectrum and anaerobic antibiotic exposure on survival following autologous stem cell transplantation in lymphoma patients.
  • Retrospective cohort study of DLBCL and HL patients undergoing ASCT from 2010 to 2022.
  • Antibiotic exposure categorized by broad-spectrum and anaerobic types during peri-transplant period.
  • Overall survival and cumulative incidence of relapse analyzed with statistical models.
  • Of 296 patients included, 80% received broad-spectrum antibiotics, with univariate analysis showing lower OS rates.
  • 5-year OS for BSA exposure was 68%, versus 75% for non-exposed; AA exposure showed similar trends.
  • Age emerged as a significant factor in OS, surpassing antibiotic impact in multivariate analysis.

Cite This Study

Anderson et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc34https://doi.org/10.1182/blood-2025-8021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of antibiotic exposure on CAR-T cell therapy outcomes: Analysis in multiple Myeloma and lymphoma2025
  2. 2Autologous Transplant (ASCT) in Patients with Chemosensitive Late Relapse of Diffuse Large B-Cell Lymphoma (DLBCL)2026
  3. 3Outcomes of autologous transplant (ASCT) in patients with chemosensitive late relapse of large B-cell lymphoma (LBCL)2025
  4. 4Hematopoietic stem cell transplantation for relapsed classical Hodgkin lymphoma: A benchmark Study on 19,498 patients from the EBMT lymphoma working party2025
  5. 5Antibiotic Use Before CAR-T Treatment Is Associated with Inferior Outcomes in DLBCL Lymphoma Patients.2026