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December 8, 2025BloodOpen Access

Single-dose IV ferric derisomaltose improves hematologic and patient-reported outcomes in pregnant individuals with iron deficiency anemia

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Authors

TKThalia Padilla KelleyKMKylee L. MartensALAdam K. Lewkowitz

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Overview

Prospective trial improved hematologic and patient-reported outcomes in pregnant individuals with severe anemia, indicating IV ferric derisomaltose is a safe and effective treatment.

Key Points

  • To evaluate the efficacy and safety of single-dose IV ferric derisomaltose in pregnant individuals with iron deficiency anemia.
  • Single-arm clinical trial conducted from January 2024 to July 2025.
  • 75 pregnant individuals with IDA received a single 1,000 mg dose of IV FDI.
  • Hematologic outcomes were assessed at baseline, delivery, and 6 weeks postpartum.
  • Mean hemoglobin increased from 10.3 g/dL to 12.9 g/dL at 6 weeks postpartum (p < 0.001).
  • 64.3% of participants had a ≥1 g/dL Hb increase prior to delivery.
  • Significant improvements in ferritin and transferrin saturation were observed at 6 weeks postpartum.

Cite This Study

Kelley et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dad0https://doi.org/10.1182/blood-2025-4682
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-dose Intravenous Iron Versus Oral Iron for Treatment of Maternal Iron Deficiency Anemia: A Randomized Clinical Trial2025
  2. 2Iron infusions in pregnant women are associated with comparable efficacy and safety compared to non-pregnant women2025
  3. 3Comparative Efficacy, Safety, and Quality-of-Life Outcomes of Oral Ferrous Sulfate Versus Intravenous Ferric Carboxymaltose in the Management of Iron Deficiency Anemia During Pregnancy2026
  4. 4Effectiveness and Safety of Intravenous Iron Therapy in Outpatient Obstetrical Clinic for Treatment of Iron‐Deficiency Anemia During Pregnancy2025
  5. 5Intravenous Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia During Pregnancy: Effects on Maternal and Fetal Wellbeing—A Multicenter Retrospective Observational Study2025