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December 8, 2025BloodOpen Access

Clinical features and outcomes of patients with non-erythrodermic mycosis fungoides with high blood tumor burden

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Authors

CTColin ThomasDLDaniel J. LandsburgSNSunita D. Nasta

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Overview

Retrospective analysis shows better survival rate for non-erythrodermic SS compared to classic SS, indicating distinct clinical features.

Key Points

  • This research aims to elucidate the clinical features and prognosis of patients with non-erythrodermic Sézary Syndrome.
  • Retrospective study conducted at the University of Pennsylvania
  • Patients diagnosed with B2 leukemic disease were identified
  • Statistical significance assessed using Fisher's exact test and Wilcoxon rank-sum test
  • Two cohorts identified: 21 non-erythrodermic SS patients, 79 classic SS patients
  • 2-year overall survival for non-erythrodermic vs classic SS was 100% vs 74%
  • 5-year overall survival was 100% for non-erythrodermic vs 34.5% for classic SS

Cite This Study

Thomas et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc91https://doi.org/10.1182/blood-2025-560
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A targeted mutational landscape of angioimmunoblastic T-cell lymphoma2013 · 430 citations
  2. 2Long-term Outcomes of 1,263 Patients with Mycosis Fungoides and Sézary Syndrome from 1982 to 20092012 · 284 citations
  3. 3Blood classification and blood response criteria in mycosis fungoides and Sézary syndrome using flow cytometry: recommendations from the EORTC cutaneous lymphoma task force2018 · 154 citations
  4. 4Survival Outcomes and Prognostic Factors in Mycosis Fungoides/Sézary Syndrome: Validation of the Revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer Staging Proposal2010 · 854 citations
  5. 5WHO-EORTC classification for cutaneous lymphomas2005 · 3,821 citations