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December 8, 2025BloodOpen Access

Azin1/tecr reprograms fatty acid metabolism to drive Acute Myeloid Leukemia progression

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Authors

FWFengjiao WangThe Fifth People's Hospital of AnyangYWYifei WangBeijing University of TechnologySYShangda YangChinese Academy of Medical Sciences & Peking Union Medical College

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Overview

This approach reveals that Azin1 regulates leukemia stem cell function and fatty acid metabolism in AML, highlighting potential therapeutic targets.

Key Points

  • The study aims to understand how Azin1 influences fatty acid metabolism and AML progression.
  • Used Vav-iCre; Azin1fl/fl mouse model to study Azin1 function in hematopoiesis
  • Conducted RNA-sequencing and metabolomics on Azin1 knockout MA9 and THP-1 cells
  • Employed mass spectrometry and Co-immunoprecipitation to investigate protein interactions
  • Azin1 knockout impaired hematopoietic reconstitution and reduced stem cell self-renewal
  • Identification of oleic acid as differentially reduced in Azin1 knockout AML cells
  • Azin1 stabilizes TECR to enhance fatty acid chain elongation, promoting AML progression

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcb5https://doi.org/10.1182/blood-2025-1464
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting ABCD1 inhibits peroxisomal fatty acid oxidation to selectively eliminate acute myeloid leukemia cells2026 · 2 citations
  2. 2Targeting METTL3 disrupts oncogenic transcriptional programs and activates immune and apoptotic pathways in Acute Myeloid Leukemia2025
  3. 3CPT1B promotes acute myeloid leukemia progression via fatty acid oxidation–dependent metabolic reprogramming2026
  4. 4Inhibition of CPT1A reverses AML1-ETO-induced differentiation blockage by activating BCL-2/MYC signaling and metabolic reprogramming2025
  5. 5Abstract 4037: Pharmacological inhibition of eIF4A1 suppresses leukemogenesis via specifically rewiring amino acid biosynthesis2026