Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

The impact of hematopoietic cell transplantation on sickle cell hepatopathy and vice versa

View Full Paper
Ask AI
Bookmark
Share

Authors

AWAmanda WalkerCFCourtney D. Fitzhugh

Discussion

Loading...

Member takes

Overview

Retrospective review shows hematopoietic cell transplantation improves liver disease metrics in sickle cell patients, indicating a beneficial relationship.

Key Points

  • This study aims to evaluate the effects of sickle cell hepatopathy on hematopoietic cell transplantation outcomes and vice versa.
  • Conducted a retrospective chart review of 19 patients with sickle cell disease who underwent nonmyeloablative HCT.
  • Evaluated pre- and post-HCT liver biopsies to assess liver pathology and HCT outcomes.
  • Utilized the Histologic Activity Index and Deugnier scoring for liver disease severity assessment.
  • 1-year overall survival and sickle cell free survival was 100%.
  • 91.7% of patients showed improvement or stability in HAI inflammation scores post-HCT.
  • 66.6% of patients with elevated pre-HCT HAI fibrosis demonstrated improvement post-HCT.

Cite This Study

Walker et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd0ehttps://doi.org/10.1182/blood-2025-7839
View Full Paper
Ask AI
Bookmark
Share