Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Impact of pre-transplant bone marrow cellularity and fibrosis on post-transplant outcomes in sickle cell disease

View Full Paper
Ask AI
Bookmark
Share

Authors

CFCourtney D. Fitzhugh

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals no impact of baseline cellularity or fibrosis on graft rejection in sickle cell disease patients after hematopoietic cell transplantation, suggesting alternative factors

Key Points

  • This research investigates the influence of pre-transplant bone marrow conditions on outcomes post-hematopoietic cell transplantation in sickle cell disease.
  • Conducted a retrospective study of patients with sickle cell disease undergoing non-myeloablative haploidentical hematopoietic cell transplantation.
  • Evaluated bone marrow samples for cellularity and fibrosis using numerical ratings and the Bauermeister grading system.
  • Compared baseline cellularity and fibrosis against metrics of transplant outcomes, such as graft rejection and clonal hematopoiesis levels.
  • 34 patients had baseline cellularity data and 26 had fibrosis data.
  • 56.4% of patients achieved sustained engraftment, while no significant difference in engraftment was found based on cellularity or fibrosis scores.
  • Patients with fibrosis scores >2 all experienced graft failure, unlike those with lower scores.

Cite This Study

Courtney D. Fitzhugh (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d612https://doi.org/10.1182/blood-2025-4304
View Full Paper
Ask AI
Bookmark
Share