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December 8, 2025Blood

Assessment of red blood cell functional biomarkers following hematopoietic cell transplantation in sickle cell disease patients

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Authors

RGRobert W. GoodrichCFCourtney D. FitzhughPHPatrick C. Hines

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Overview

Assessment shows normalization of red blood cell function in sickle cell disease patients post hematopoietic cell transplantation, suggesting potential biomarkers for therapy efficacy.

Key Points

  • This research aims to evaluate the functional biomarkers of red blood cells after hematopoietic cell transplantation in sickle cell disease patients.
  • Assessed RBC biomarkers using flow adhesion to VCAM and a dynamic sickling assay
  • Collected blood samples from eight sickle cell disease patients at various time points post-transplantation
  • Compared outcomes in patients with successful engraftment versus graft failure
  • Successful engraftment correlated with significant decreases in RBC adhesion and sickling kinetics
  • FA-WB-VCAM values decreased significantly from baseline to three and twelve months post-transplant
  • Graft failure patients did not maintain reduced RBC parameters, indicating potential predictive biomarkers

Cite This Study

Goodrich et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e489https://doi.org/10.1182/blood-2025-1160
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Also Consider

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  1. 1Blood Rheology After Allogeneic Hematopoietic Stem Cell Transplantation or Gene Therapy in Sickle Cell Disease2026
  2. 2Predicting donor engraftment success in adults post haploidentical bone marrow transplant for sickle cell disease: BMT CTN 15072025 · 1 citations
  3. 3Real-world Assessment of Red Blood Cell (RBC) Health Biomarkers in Sickle Cell Disease2024
  4. 4Pulmonary Function after Nonmyeloablative Hematopoietic Cell Transplant for Sickle Cell Disease2024 · 6 citations
  5. 5Effect of Hematopoietic Cell Transplantation on Inflammatory and Angiogenic Plasma Proteins in Sickle Cell Disease2026