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December 8, 2025Blood

Predicting donor engraftment success in adults post haploidentical bone marrow transplant for sickle cell disease: BMT CTN 1507

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Authors

CLChristopher A. LazarskiCBCatherine M. Bollard

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Overview

Clinical trial demonstrates high donor engraftment in sickle cell disease patients, indicating potential intervention benefits.

Key Points

  • To evaluate HLA-specific assays as predictors for donor engraftment in sickle cell disease post-transplant.
  • Utilized a multicenter clinical trial to analyze patient samples at multiple time points post-transplant.
  • Performed HLA typing and donor chimerism testing using a novel flow cytometry-based assay (HFA).
  • Collected peripheral blood mononuclear cells (PBMCs) from patients and donors for chimerism analysis.
  • 97% of patients demonstrated sustained donor engraftment at 1 year.
  • HFA testing indicated early risks for graft failure before clinical detection in two patients.
  • Lymphocyte donor chimerism peaked at day +365, with minimal variability among patients.

Cite This Study

Lazarski et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1a9https://doi.org/10.1182/blood-2025-2472
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of red blood cell functional biomarkers following hematopoietic cell transplantation in sickle cell disease patients2025
  2. 2Flow Cytometry–Based Optimisation of HLA-A24 Chimerism Monitoring in Haploidentical Haematopoietic Stem Cell Transplantation-- A Preliminary Study2025
  3. 3Impact of pre-transplant bone marrow cellularity and fibrosis on post-transplant outcomes in sickle cell disease2025
  4. 4Post-transplant monitoring of multiparameter flow-cytometry (MFC)-based measurable residual disease (MRD) assessment combined with T-cell chimerism following allogeneic stem cell transplantation (HCT) in Acute Myeloid Leukemia (AML) and myelodysplastic syndrome (MDS)2025
  5. 5Reduced intensity haploidentical bone marrow transplantation in children with severe sickle cell disease (SCD): BMT CTN 15072025 · 4 citations