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December 8, 2025Blood

Healthcare transition readiness for sickle cell disease: A high- and low- income comparative analysis

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Authors

JPJerlym S. PorterSt. Jude Children's Research HospitalDSDaniela SalaClinical Emergency Hospital BucharestTOThais OliveiraUniversidade Federal do Rio de Janeiro

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Implication

Analysis reveals disparities in healthcare transition readiness for sickle cell disease in adolescents and young adults across Brazil and the US, highlighting critical access issues.

Key Points

  • To evaluate transition readiness for adolescents and young adults with sickle cell disease across Brazil and the US.
  • SMSC administered to AYAs aged 12-21 at leading SCD centers in Brazil and the US.
  • Descriptive statistics, Chi-square tests and t-tests compared demographic and clinical variables.
  • Multivariable linear regression assessed associations between SMSC scores and participant characteristics.
  • Higher age associated with increased HCT readiness scores (p<0.01).
  • Chronic transfusion and hydroxyurea use linked to higher overall and skill scores.
  • Brazilian AYAs scored significantly lower than US peers in all domains (p<0.01).

Cite This Study

Porter et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddfdhttps://doi.org/10.1182/blood-2025-4740
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tailoring pediatric to adult care transition from high to low-resource settings: A user-centered design approach2025
  2. 2Implementation of a pediatric-to-adult care transition program for sickle cell disease in Brazil: a contextual evaluation2026
  3. 3Psychometric evaluation of the self-management skills checklist across Brazil and the United States: Toward global measurement of transition readiness in sickle cell disease2025
  4. 4Hematopoietic stem cell transplantation with reduced toxicity myeloablative conditioning regimen for children and adults with sickle cell disease: A brazilian single center experience.2025
  5. 5Evaluating a Pediatric to Adult Care Transition Program for Adolescents and Young Adults With Sickle Cell Disease: A Program Assessment at Duke University2026