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December 8, 2025BloodOpen Access

Enhancing hemostasis in glanzmann thrombasthenia via protein S inhibition

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Authors

MFMathieu FioreLSLéonard Julien Simon Schacher

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Overview

Experimental study found PS inhibition improves thrombin generation in Glanzmann thrombasthenia, suggesting new treatment avenues.

Key Points

  • To evaluate the efficacy of PS-siRNA in enhancing thrombin generation and providing prophylactic protection against bleeding in Glanzmann thrombasthenia.
  • Utilized αIIbβ3⁻/⁻ mice as a genetic model of Glanzmann thrombasthenia.
  • Administered a single subcutaneous injection of PS-siRNA or control.
  • Measured thrombin generation with a thrombin generation assay from platelet-rich plasma samples.
  • Assessed splenic weights as markers of bleeding severity and splenomegaly.
  • PS-siRNA treated mice exhibited no visible bleeding, contrasting with controls showing significant bleeding.
  • Endogenous thrombin potential significantly increased in PS-siRNA treated mice.
  • Reduced splenomegaly was observed in PS-siRNA treated mice compared to controls.
  • Increased thrombin generation noted in GT patient PRP with anti-PS antibody treatment.

Cite This Study

Fiore et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df30https://doi.org/10.1182/blood-2025-3025
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Also Consider

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