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January 1, 2009Thrombosis and Haemostasis

Glanzmann’s thrombasthenia (defective platelet integrin αIIb-β3): proposals for management between evidence and open issues

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Key result

Management proposals for Glanzmann's Thrombasthenia rely on expert opinion and limited evidence, utilizing local measures, antifibrinolytics, platelet transfusions, and recombinant Factor VII.

Population

Patients with Glanzmann's Thrombasthenia (GT), a rare autosomal recessive bleeding disorder

Design

Review

Authors

GMGiovanni Di MinnoMMMatteo Nicola Dario Di MinnoMPMan-Chiu Poon

Discussion

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Overview

Expert proposals for Glanzmann's Thrombasthenia warrant cautious adoption; leaves open the need for prospective trials to guide care.

Structured PICO

P
Population
Patients with Glanzmann's Thrombasthenia (GT), a rare autosomal recessive bleeding disorder
I
Intervention
Management strategies including local measures, antifibrinolytic agents, hormone treatment, platelet transfusions, and recombinant activated Factor VII

Provides proposals for the clinical management of Glanzmann's Thrombasthenia based on expert opinion and limited evidence, highlighting the need for prospective data collection.

Limitations

  • Limited evidence in the area
  • Rarity and heterogeneity of inherited platelet abnormalities
  • limited evidence in the area
  • rarity and heterogeneity of inherited platelet abnormalities

Cite This Study

Minno et al. (2009) conducted a review in Glanzmann's Thrombasthenia. Clinical management strategies was evaluated. Management proposals for Glanzmann's Thrombasthenia rely on expert opinion and limited evidence, utilizing local measures, antifibrinolytics, platelet transfusions, and recombinant Factor VII.

synapsesocial.com/papers/6a9e8f3d65b09fbae72cb0d0https://doi.org/10.1160/th09-04-0225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glanzmann’s thrombasthenia: strategies for identification and management2017 · 7 citations
  2. 2Glanzmann thrombasthenia presenting with upper gastrointestinal bleeding: a case series and review of the literature2026
  3. 3European Management of Glanzmann's Thrombasthenia: A Survey of Current Clinical Practice2025 · 3 citations
  4. 4Intraoperative Bleeding During Mammoplasty and Dermolipectomy: A Case of Glanzmann's Thrombasthenia2025
  5. 5Platelet transfusion refractoriness in Glanzmann thrombasthenia: a case report with literature review2026