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December 8, 2025Blood

Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients

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Authors

SYShunsuke YamamotoYKYuhki KogaKAKoichi Akashi

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Overview

Observational study shows platelet-rich plasma significantly improves counts in pediatric ALL patients after apheresis, indicating potential risks in low-weight individuals.

Key Points

  • Investigate thrombocytopenia and the efficacy of platelet-rich plasma return during CAR-T apheresis in low-weight pediatric patients with ALL.
  • Analysis of 144 lymphocyte apheresis sessions from 2019 to 2024
  • Focused subgroup analysis on pediatric patients weighing less than 25 kg
  • Recorded pre- and post-apheresis platelet counts and subsequent PRP return effects
  • Platelet counts decreased by a median of 77 × 10⁹/L post-apheresis
  • PRP return raised platelet counts to a median of 122 × 10⁹/L after declines
  • Age, weight, and processed blood volume correlated with platelet decrease

Cite This Study

Yamamoto et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfdahttps://doi.org/10.1182/blood-2025-7702
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Individualizing apheresis processing volumes using a predictive algorithm: Analysis of the CAR T-cell collection protocol utilized in ACIT001/EXC002, a phase lb/ll trial of decentralized production of CAR T-cells for treatment of relapsed/refractory aggressive NHL and ALL2025
  2. 2Peripheral blast count at apheresis as a risk factor for survival following tisagenlecleucel in children and young adults2025
  3. 3Correlation of T cell fitness of apheresis products with response to CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma: A prospective observational study at a single center2025
  4. 4Poor neutrophil recovery following CD19-targeted CAR-T cell therapy predicts inferior outcomes in adult patients with B-cell lymphoma2025
  5. 5TPO-ras for persistent thrombocytopenia following CAR-T therapy in multiple myeloma: A multicenter clinical experience2025