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December 8, 2025BloodOpen Access

Individualizing apheresis processing volumes using a predictive algorithm: Analysis of the CAR T-cell collection protocol utilized in ACIT001/EXC002, a phase lb/ll trial of decentralized production of CAR T-cells for treatment of relapsed/refractory aggressive NHL and ALL

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Authors

JCJennifer CrodenCDCarina Debes-MarunISIrwindeep Sandhu

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Overview

A predictive algorithm improves T-cell collection efficiency in patients undergoing CAR T-cell treatment.

Key Points

  • Evaluate a predictive algorithm for personalized apheresis processing in CAR T-cell collection.
  • Adult patients with R/R NHL or ALL underwent T-cell collection during a clinical trial.
  • Patients' absolute T-cell counts were calculated using baseline lymphocyte counts and flow cytometry.
  • Estimated time on machine for apheresis was calculated to meet target CD3+ lymphocyte counts.
  • 29 patients completed T-cell collection with 93% achieving the target CD3+ count.
  • Accurate predictions of required apheresis time were made in 72% of cases.
  • Group B patients had significantly smaller TBV and longer estimated times on machine.

Cite This Study

Croden et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db3ehttps://doi.org/10.1182/blood-2025-5962
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation of T cell fitness of apheresis products with response to CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma: A prospective observational study at a single center2025
  2. 2Apheresis CD8+CCR7+CD45RA− T-Cells as a Novel Biomarker Associated with CAR T-Cell Kinetics and Clinical Outcome2026 · 1 citations
  3. 3Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients2025
  4. 4Lymphocyte kinetics as a predictor of clinical outcomes following CAR-T therapy for non-Hodgkin lymphoma2025
  5. 5Advantages of high cell concentration prior to cryopreservation of initial leukapheresis in CAR-T cell therapy.2024 · 2 citations