What question did this study set out to answer?

To evaluate the efficacy of CCND1 immunohistochemistry as a diagnostic surrogate for the t(11;14) translocation in AL amyloidosis.

December 8, 2025BloodOpen Access

Cyclin D1 immunostaining as a diagnostic surrogate for the t(11;14) translocation in AL amyloidosis

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Retrospective analysis supports immunostaining for Cyclin D1 to detect t(11;14) in AL amyloidosis, indicating high accuracy rates in diagnosis.

To evaluate the efficacy of CCND1 immunohistochemistry as a diagnostic surrogate for the t(11;14) translocation in AL amyloidosis.
Single-center, retrospective study
Patients with AL amyloidosis evaluated at Boston University
Bone marrow biopsies analyzed for CCND1 expression and t(11;14) status by FISH
Dual IHC staining performed on biopsy specimens for accurate assessment.
Out of 131 patients, 69 (53%) tested positive for t(11;14) using FISH.
CCND1 IHC showed 50% concordance with positive t(11;14) results by FISH.
Sensitivity of CCND1 IHC for detecting t(11;14) was 96%, with a specificity of 89%.
The correlation between CCND1 expression and BMPC percentage was modest (r = 0.34).

Andrew Staron (2025) studied this question.

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Retrospective analysis supports immunostaining for Cyclin D1 to detect t(11;14) in AL amyloidosis, indicating high accuracy rates in diagnosis.