December 8, 2025Blood
Disease characteristics, treatment patterns, and outcomes of AL amyloidosis patients with high-risk FISH cytogenetics
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Discussion
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Implication
Retrospective analysis shows hematologic responses in AL amyloidosis with high-risk FISH, suggesting need for personalized treatments.
Key Points
- This study aims to evaluate the implications of high-risk FISH cytogenetics in AL amyloidosis patients.
- Retrospective analysis of 698 newly diagnosed AL amyloidosis patients at Mayo Clinic from 2012 to 2021
- Compared baseline characteristics and treatment patterns between high-risk and standard-risk groups
- Assessed hematologic, cardiac, and renal responses at multiple time points using consensus criteria.
- 10.4% of patients had high-risk FISH abnormalities, with t(14;16) being the most common
- Higher hematologic overall response rates and deeper organ responses were observed in the high-risk group
- Multivariable analysis indicated that age and organ involvement affect overall survival, while high-risk FISH did not independently influence survival.
Cite This Study
Dispenzieri et al. (2025) studied this question.