What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 3, Pre-Registered Trial).

What question did this study set out to answer?

The analysis aims to evaluate the impact of central versus local MRD assessments on patient outcomes in AML trials.

December 8, 2025Blood

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Multicenter randomized study shows expert verification of MRD enhances prognostic value in AML patients receiving chemotherapy.

The analysis aims to evaluate the impact of central versus local MRD assessments on patient outcomes in AML trials.
Compared local and central MRD assessments
Evaluated impact on relapse-free survival and overall survival
Used data from a multicenter randomized phase 3 trial
Analyzed MRD data from multiple laboratories and assessed concordance with central review
Concordance between local and central MRD assessments was variable
Cohen's kappa for MRD1 was 0.15, indicating poor agreement
Centrally reviewed MRD2 had significant prognostic value with a hazard ratio of 2.32
Local MRD assessments showed limited prognostic value in overall survival

Woźniczka et al. (2025) studied this question.

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