Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Apheresis blood processing with heparin improves stem cell collection outcomes for sickle cell gene therapy

View Full Paper
Ask AI
Bookmark
Share

Authors

CHCarly HowardASAimee SarnieSNSarah Nikiforow

Discussion

Loading...

Member takes

Overview

This trial demonstrates improved Hematopoietic progenitor cell collection efficiency in sickle cell disease with heparin, suggesting enhanced gene therapy outcomes.

Key Points

  • To evaluate the impact of heparin on stem cell collection outcomes in sickle cell disease during apheresis.
  • Compared outcomes of apheresis using heparin with standard ACD-A anticoagulation.
  • Conducted 91 HPC apheresis procedures in 26 sickle cell disease patients.
  • Patients received plerixafor for mobilization and two heparin boluses prior to apheresis.
  • Collection efficiency improved with heparin (mean 50% vs 39%, p=0.02).
  • Higher CD34+ cell yield with heparin (mean 5.5 × 10⁶ vs 3.4 × 10⁶ cells/kg, p=0.0007).
  • Significantly fewer access pressure alarms occurred with heparin (2% vs 21%).

Cite This Study

Howard et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e142https://doi.org/10.1182/blood-2025-6096
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Citrate Versus Citrate–Heparin Anticoagulation in <scp>HPC</scp> (A): Comparative Effects on Intra‐Apheresis Mobilization of <scp>CD34</scp> <sup>+</sup> Hematopoietic Progenitor Cells2026
  2. 2Pediatric autologous peripheral blood stem cell collection without heparin using a highly concentrated sodium citrate anticoagulant: A retrospective comparison with standard <scp>ACD</scp> ‐A2026
  3. 3Highly efficient collection and manufacture of autologous HSC gene therapy cell product for patients with sickle cell disease using a lentiviral vector containing a shmir targeting BCL11a2025 · 1 citations
  4. 4How do I overcome apheresis collection challenges for sickle cell disease gene therapy2025 · 1 citations
  5. 5Toward Universal Single-Session Allogeneic Peripheral Blood Stem Cell Collection: An Algorithm-Guided Approach2026