What question did this study set out to answer?

This research aims to evaluate the effectiveness of dual targeting of FXII and Gas6 in preventing thrombosis without increasing bleeding risk.

December 8, 2025BloodOpen Access

Is dual targeting of FXII and Gas6 a good strategy to prevent thrombosis with no risks of bleeding?

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Authors

ISIlaria De Simone AAAnne Angelillo‐Scherrer

Discussion

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Overview

Double knockout mice revealed that dual targeting reduces thrombus stability while preventing bleeding, suggesting implications for antithrombotic strategies.

Key Points

This research aims to evaluate the effectiveness of dual targeting of FXII and Gas6 in preventing thrombosis without increasing bleeding risk.
Generated a double knockout mouse lacking both FXII and Gas6 as well as control groups.
Assessments included tail bleeding assay, venous thromboembolism model, ultrahigh-frequency ultrasound, and intravital confocal microscopy.
Analyzed platelet aggregation, fibrinolysis, clot ultrastructure, and neutrophil extracellular trap formation.
F12-/-Gas6-/- mice showed no bleeding tendency with shorter bleeding times in tail assays compared to controls.
Survival after VTE induction was significantly higher in knockout mice compared to WT, indicating reduced thrombus stability.
Knockout mice had faster fibrinolysis and reduced NET formation, indicating potential instability in thrombi.

Cite This Study

Simone et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e18e https://doi.org/10.1182/blood-2025-14

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December 8, 2025BloodOpen Access

Is dual targeting of FXII and Gas6 a good strategy to prevent thrombosis with no risks of bleeding?

View Full Paper

Ask AI

Bookmark

Authors

ISIlaria De Simone AAAnne Angelillo‐Scherrer

Discussion

Member takes

Overview

Double knockout mice revealed that dual targeting reduces thrombus stability while preventing bleeding, suggesting implications for antithrombotic strategies.

Key Points

This research aims to evaluate the effectiveness of dual targeting of FXII and Gas6 in preventing thrombosis without increasing bleeding risk.
Generated a double knockout mouse lacking both FXII and Gas6 as well as control groups.
Assessments included tail bleeding assay, venous thromboembolism model, ultrahigh-frequency ultrasound, and intravital confocal microscopy.
Analyzed platelet aggregation, fibrinolysis, clot ultrastructure, and neutrophil extracellular trap formation.
F12-/-Gas6-/- mice showed no bleeding tendency with shorter bleeding times in tail assays compared to controls.
Survival after VTE induction was significantly higher in knockout mice compared to WT, indicating reduced thrombus stability.
Knockout mice had faster fibrinolysis and reduced NET formation, indicating potential instability in thrombi.

Cite This Study

Simone et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e18e https://doi.org/10.1182/blood-2025-14

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