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December 8, 2025BloodOpen Access

Normal B Cells in MBL follow divergent maturation pathways that correlate with the IGHV mutation status of the pre-leukemic clone

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Authors

XYXiao‐Jie YanANAnita NgLSLadys Sarmiento

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Overview

Transcriptome analysis reveals distinct maturation pathways in normal B cells of high-count MBL cases, suggesting different immune challenges.

Key Points

  • The study aims to investigate the maturation pathways of normal B cells in monoclonal B-cell lymphocytosis and their correlation with IGHV mutation status.
  • Compared transcriptomes of normal B cells from healthy donors and high-count and low-count MBL patients.
  • Analyzed B-cell subset distribution and BCR repertoires using flow cytometry and RNA sequencing.
  • Conducted PCA and pathway enrichment analysis on gene expression data.
  • Transcriptome differences were observed between normal B cells of patients with different MBL types and healthy donors.
  • B-cell subsets showed distinct distributions and potential functional defects across MBL groups.
  • High-count MBL displayed a more restricted and hypermutated BCR repertoire compared to low-count MBL and healthy controls.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1bahttps://doi.org/10.1182/blood-2025-3910
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