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December 8, 2025BloodOpen Access

Disruption of intestinal homeostasis reflected by DAO and microbiota alterations in gvhd post-HSCT.

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Authors

SSShotaro ShiratoMKMasayoshi Kobune

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Overview

Retrospective analysis shows alterations in gut microbiota and biomarkers in GVHD post-HSCT, indicating intestinal dysbiosis involvement.

Key Points

  • The research aims to examine the relationship between GVHD onset and changes in DAO activity and gut microbiota composition after HSCT.
  • Analyzed 19 HSCT patients retrospectively at Sapporo Medical University Hospital.
  • Measured plasma DAO activity and serum DAO concentration.
  • Conducted gut microbiota profiling using next-generation sequencing.
  • Nine patients developed grade 2–4 GVHD requiring systemic therapy.
  • Marked inter-individual variability was observed in serum DAO concentration and plasma DAO activity.
  • Microbial diversity decreased post-transplant, more severely in the GVHD group.

Cite This Study

Shirato et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e208https://doi.org/10.1182/blood-2025-2457
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  2. 2Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study2024 · 12 citations
  3. 3Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients2025
  4. 4Effect of GVHD on the gut and intestinal microflora2024 · 6 citations
  5. 5Early gut microbiome metabolites and diversity predict GVHD-free survival after allogeneic hematopoietic cell transplantation2026