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December 8, 2025Blood

Identification of a development-restricted, megakaryocyte-primed population of hematopoietic progenitor cells during fetal and early postnatal development

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Authors

RTRohit ThallaKJKanak Joshi

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Overview

Characterization reveals megakaryocyte progenitors exhibit distinct gene profiles in hematopoietic development, indicating potential implications for leukemia.

Key Points

  • To characterize development-restricted megakaryocyte-primed progenitor cells during fetal and postnatal hematopoiesis.
  • Used α-catulin-GFP reporter mice for tracking HSPC populations.
  • FACS isolation of HSCs and progenitor cells from different developmental stages.
  • Performed bulk RNA-sequencing and gene set enrichment analysis to assess gene profiles and pathways.
  • GFP+ megakaryocyte progenitors showed higher expression of MK-related genes compared to GFP- progenitors.
  • Postnatal GFP+ cells produced more megakaryocytes and exhibited slower differentiation.
  • Transplantation showed GFP+ MPP2s had superior engraftment efficiency in reconstituting hematopoietic lineages.

Cite This Study

Thalla et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e23dhttps://doi.org/10.1182/blood-2025-4936
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Also Consider

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  1. 1Adult megakaryopoiesis: when taking a short-cut results in a different final destination2024
  2. 2CD27, CD62L and ESAM define a multipotent progenitor population with megakaryocytic potential2025
  3. 3A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis2024 · 2 citations
  4. 4A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis2025 · 4 citations
  5. 5A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging2024 · 2 citations