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November 28, 2025Proceedings of the National Academy of SciencesOpen Access

Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees

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Authors

FSFuwei ShangTNTamar NizharadzeRTRobin Thiele

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Overview

Observational analysis reveals distinct hematopoietic stem cells and multipotent progenitor lineages, suggesting diverse contributions to hematopoiesis.

Key Points

  • Distinct hematopoiesis lineage trees arise from separate multipotent progenitor cell origins, specifically eMPP and hMPP.
  • The study finds that eMPP contribute to about 35% of hematopoiesis, primarily directing lymphoid differentiation.
  • Analysis utilizing techniques such as in situ barcoding and PolySMART demonstrates clear transcriptomic differences between multipotent progenitor populations.
  • These findings indicate that understanding multipotent progenitor dynamics may unveil novel strategies to address hematopoietic aging.

Cite This Study

Shang et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a65ehttps://doi.org/10.1073/pnas.2505510122
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees2025 · 3 citations
  2. 2A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis2025 · 4 citations
  3. 3A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis2024 · 2 citations
  4. 4Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed2024 · 4 citations
  5. 5CD27, CD62L and ESAM define a multipotent progenitor population with megakaryocytic potential2025