What question did this study set out to answer?

To determine whether asymmetric cell divisions in human multipotent hematopoietic progenitors foster self-renewal or direct lineage specification.

October 24, 2014Stem Cell ReportsOpen Access

Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages

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Authors

AGAndré GörgensKarolinska University Hospital ALAnna‐Kristin LudwigLudwig-Maximilians-Universität München MMMichael MöllmannEssen University Hospital

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Implication

Single-cell tracking demonstrates asymmetric division instructs lineage commitment in human multipotent hematopoietic progenitors, indicating divisions drive differentiation rather than self-renewal.

Key Points

To determine whether asymmetric cell divisions in human multipotent hematopoietic progenitors foster self-renewal or direct lineage specification.
Tracked asymmetric CD133 segregation in paraformaldehyde-fixed and living human hematopoietic stem and progenitor cells using the novel HC7 antibody.
Evaluated the developmental potential and lineage fate of individual daughter cells derived from isolated multipotent progenitor fractions at the single-cell level.
Approximately 70% of the studied multipotent progenitor (MPP) fraction underwent asymmetric cell divisions.
About 25% of asymmetric divisions produced one lymphoid-primed multipotent progenitor (LMPP) and one erythromyeloid progenitor (EMP) daughter cell.
Daughter cells rarely maintained parental MPP characteristics under standard culture conditions, indicating that asymmetric divisions instruct lineage fate rather than preserve stemness.

Cite This Study

Görgens et al. (2014) studied this question.

synapsesocial.com/papers/6a892d3bcd9902a7ca128091 https://doi.org/10.1016/j.stemcr.2014.09.016

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Implication

Single-cell tracking demonstrates asymmetric division instructs lineage commitment in human multipotent hematopoietic progenitors, indicating divisions drive differentiation rather than self-renewal.

Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages

Discussion

Member takes

Implication

Key Points

Cite This Study

Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages

Discussion

Member takes

Implication

Key Points

Cite This Study

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