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December 8, 2025Blood

CD27, CD62L and ESAM define a multipotent progenitor population with megakaryocytic potential

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Authors

LZLei ZhangWWWei Wei

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Overview

Experiment uncovered that multipotent progenitor populations exhibit heterogeneous gene-expression, suggesting CD27 and CD62L define distinct megakaryocytic potential groups.

Key Points

  • To identify surface markers that define multipotent progenitor populations with megakaryocytic potential and resolve their functional heterogeneity.
  • Utilized single cell and lineage-tracing techniques to analyze hematopoietic lineage specification.
  • Investigated candidate surface markers in adult murine bone marrow with spectral flow cytometry.
  • Performed phenotypic, transcriptomic, and functional analyses, including FACS sorting and colony assays.
  • CD27, CD62L, and ESAM defined heterogeneous multipotent progenitor populations with varying megakaryocyte lineage potential.
  • C1 population exhibited the highest clonogenicity potential, producing a range of blood progenitors including megakaryocytes.
  • ESAM+ subsets showed superior megakaryocyte production and multilineage engraftment compared to ESAM– subsets.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e246https://doi.org/10.1182/blood-2025-4935
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a development-restricted, megakaryocyte-primed population of hematopoietic progenitor cells during fetal and early postnatal development2025
  2. 2A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis2024 · 2 citations
  3. 3Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees2025
  4. 4Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees2025 · 3 citations
  5. 5A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis2025 · 4 citations