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December 8, 2025BloodOpen Access

Incidence and diagnosis of iron deficiency among patients receiving a blood transfusion in the emergency department

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Authors

AJAyaan JamaliMSMarwan Shaikh

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Overview

Retrospective cohort study reveals high incidence of iron deficiency anemia in emergency department patients, highlighting diagnosis management gaps.

Key Points

  • To characterize the incidence of iron deficiency in patients receiving blood transfusions in the emergency department.
  • Retrospective cohort study of adults with severe anemia receiving PRBC transfusions in ED.
  • Patients assessed for iron deficiency based on MCV, ferritin, and iron saturation levels.
  • B12 and folate levels recorded to determine deficiencies.
  • 210 patients (45%) identified at risk for iron deficiency; 136 (29%) confirmed iron deficiency.
  • Iron deficiency not always presenting with microcytosis; variability in MCV levels observed.
  • 3% of patients had B12 deficiency, highlighting need for comprehensive assessments.

Cite This Study

Jamali et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2b7https://doi.org/10.1182/blood-2025-6466
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating the management of severe anemia in the emergency department: A single-center analysis2025
  2. 2First‐time red blood cell transfusions in the emergency department: A deficiency in micronutrient testing2026
  3. 3Utilization of Intravenous Iron Therapy and Red Blood Cell Transfusion in Emergency Department Patients with Anemia: A Single-Center Retrospective Cohort Study2026
  4. 4Mind the Gap: Underdosing of Intravenous Iron in a Hospitalized Patient Population With Iron‐Deficiency Anemia2026
  5. 5Assessing clinical practice variation and provider comfort in the management of pediatric iron deficiency anemia in the acute care setting2025