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December 8, 2025BloodOpen Access

Outcomes of long-term anticoagulation use in patients hospitalized with sickle cell vaso-occlusive crisis: A weighted analysis of the national inpatient sample (2016–2022)

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Authors

AYAkeem YusufAKAbdulrahman Al Kotob

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Overview

Weighted analysis finds long-term anticoagulation increases thrombotic risk in sickle cell patients, indicating careful management is needed.

Key Points

  • Evaluate the association between long-term anticoagulation and inpatient outcomes for sickle cell vaso-occlusive crisis.
  • Weighted retrospective analysis of National Inpatient Sample from 2016-2022
  • Identified adult hospitalizations for sickle cell vaso-occlusive crisis
  • Used multivariable logistic and linear regression for analysis
  • Analyzed 581,319 hospitalizations for sickle cell crisis, with 13.2% on anticoagulation
  • Higher rates of pulmonary embolism (3.6% vs. 0.9%) and deep vein thrombosis (1.0% vs. 0.2%) in anticoagulated patients
  • Anticoagulated patients had 9.7% lower odds of needing red blood cell transfusion, but similar inpatient mortality rates.

Cite This Study

Yusuf et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2d9https://doi.org/10.1182/blood-2025-6500
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Venous thromboembolism in adults with sickle cell disease: A national inpatient sample analysis (2016–2020)2025
  2. 2Outcomes among patients with non‐ST‐elevation myocardial infarction on chronic anticoagulation: Insights from the National Inpatient Sample2024 · 1 citations
  3. 3Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis2025
  4. 4Anticoagulation and lung cancer mortality: A National Inpatient Sample analysis 2020.2024
  5. 5Pilot study on thrombosis risk factors in sickle cell anemia2025