Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

A prognostic model integrating disease‑ and patient‑oriented factors identifies poor‑outcome patients with low‑risk MDS: A multicenter real‑world cohort study (KOTOSG)

View Full Paper
Ask AI
Bookmark
Share

Authors

TNTakahisa NakamuraHOHaruya OkamotoTTTaku Tsukamoto

Discussion

Loading...

Member takes

Overview

A multicenter cohort study demonstrates a prognostic model incorporating nutritional and inflammatory factors to improve outcomes in low-risk myelodysplastic syndromes.

Key Points

  • To develop a comprehensive prognostic score that integrates inflammatory and nutritional markers to predict outcomes in low-risk myelodysplastic syndromes (LR-MDS).
  • Retrospective cohort of adults with newly diagnosed LR-MDS across nine institutions.
  • Categorization of LR-MDS risk using Revised International Prognostic Scoring System (IPSS-R).
  • LASSO-penalized Cox model used to develop a prognostic model based on identified variables.
  • Seven variables identified for the final prognostic model with a C-index of 0.85.
  • Median overall survival for good-risk, intermediate-risk, and poor-risk groups was 120.1, 51.2, and 15.7 months respectively.
  • Prognostic score (KPSS-L) outperformed IPSS-R in classifying risk levels.

Cite This Study

Nakamura et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e422https://doi.org/10.1182/blood-2025-5633
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From chaos to clarity? decoding the inflammatory profiles in lower-risk MDS2025
  2. 2Integrated machine learning-based prognostic models for patients with Myelodysplastic Syndromes/neoplasms (MDS)2025
  3. 3Improving MDS Risk Assessment: The Role of Monocytopenia and Lymphocytopenia Beyond IPSS-R2025 · 1 citations
  4. 4Association between lymphocyte-associated ratios, C-reactive protein and prognostic value in myelodysplastic syndromes2025 · 2 citations
  5. 5Comparative Analysis of IPSS, IPSS-R, and WPSS for Predicting Survival and Leukemic Transformation in Myelodysplastic Neoplasms: A Real-World Single-Center Experience.2025