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December 8, 2025Blood

Molecular stratification of relapse risk post-allogeneic hematopoietic stem cell transplantation in myeloid neoplasms with non-adverse risk cytogenetics

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Authors

ABAnmol BaranwalKHKhalil HassanHAHassan B. Alkhateeb

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Overview

Retrospective analysis identifies mutation-associated relapse risk in myeloid neoplasms, suggesting improved prognostication.

Key Points

  • To assess the impact of mutations on relapse risk post-alloHCT in patients with non-adverse-risk cytogenetics.
  • Retrospective review of patients undergoing alloHCT at Mayo Clinic Rochester
  • Identified mutation types and burdens in patients with myeloid neoplasms
  • Analyzed cumulative incidence of relapse and relapse-free survival using competing risk models
  • Of 585 patients, 215 met inclusion criteria with diverse diagnoses including AML, MDS, and CMML.
  • SF3B1 and FLT3 mutations identified as significant predictors of relapse post-alloHCT.
  • Decision tree model stratified patients into high, intermediate, and low-risk relapse groups based on genetic mutations.

Cite This Study

Baranwal et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e42ehttps://doi.org/10.1182/blood-2025-6073
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic covariates associated with outcomes in patients with <i>NPM1</i>-mutated acute myeloid leukemia2025 · 3 citations
  2. 2TP53, EZH2, or RUNX1 mutations predict poor outcomes in ELN 2022 adverse risk group of adult AML patients undergoing allo-HSCT2025
  3. 3Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWP2025
  4. 4Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study2025
  5. 5Prognostic impact of clinico-genetic characteristics and donor types in <i>NPM1</i> -mutated AML undergoing allogeneic hematopoietic stem cell transplantation2026