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December 8, 2025Blood

Identifying biological differences between two clinical risk groups of cutaneous CD30+ T cell lymphoproliferative disorders

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Authors

CCChee Leong ChengAEAndrew EvansSLSirpa Leppä

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Overview

Retrospective analysis identifies gene expression profiles and treatment impacts on survival in cutaneous CD30+ T LPD.

Key Points

  • The aim is to identify biological differences between clinical risk groups in cutaneous CD30+ T cell lymphoproliferative disorders.
  • Retrospective clinical data and skin biopsies were collected from multiple institutions.
  • Patients were grouped based on treatment received: cytotoxic chemotherapy or other treatments.
  • Whole exome DNA and whole transcriptome RNA sequencing were performed on skin biopsy samples.
  • 79 patients included with various diagnoses related to CD30+ T cell LPD.
  • Median overall survival was 14.95 years, with group 0 showing a median OS of 24.44 years and group 1 at 7.21 years.
  • Identified recurrent mutations in 18 genes, with no differences in mutation frequency between risk groups.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e448https://doi.org/10.1182/blood-2025-1747
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Also Consider

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  5. 5Abstract 3833: Primary cutaneous diffuse large B-cell lymphoma-leg type and clinicopathologic determinants of survival: Analysis of a pooled database2024