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December 12, 2025Journal of Cutaneous Pathology

Primary Cutaneous CD30 ‐Positive Lymphoproliferative Disorder With Gamma‐Delta T‐Cells: A Molecular‐Annotated Case With a Classic Clinical Appearance and Behavior

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Authors

DWDavid M. WeinerJCJoi B. CarterFLFrederick Lansigan

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Overview

Case reveals indolent CD30-positive lymphoproliferative disorder in a patient, indicating complex molecular factors.

Key Points

  • This case study examines a patient diagnosed with CD30-positive lymphoproliferative disorder involving gamma-delta T-cells.
  • Followed the patient for 4 years with conservative management
  • Conducted multiple biopsies to assess condition
  • Performed sequencing to identify mutations and copy-number changes
  • Identified missense mutations in genes including ERBB2 and LRP1B
  • Observed aneuploidy with gain of 1q and loss of 16q and 19p13.3
  • Matter of diagnosis deemed insufficient for primary cutaneous gamma-delta T-cell lymphoma

Cite This Study

Weiner et al. (2025) studied this question.

synapsesocial.com/papers/6941aae10f5af7fd17df5989https://doi.org/10.1111/cup.70043
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lymphomatoid Papulosis With T-cell Receptor–Gamma Delta Expression2024 · 7 citations
  2. 2Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas2020 · 100 citations
  3. 3Retreatment with brentuximab vedotin in patients with CD30-positive hematologic malignancies2014 · 178 citations
  4. 4The First Case of Gamma-Delta Primary Cutaneous Anaplastic Large Cell Lymphoma?2022 · 2 citations