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This research aims to explore magnetic separation methods for enhancing the removal of sickle red blood cells.

December 8, 2025BloodOpen Access

Using a magnetic column separator to determine the magnetophoretic behavior and adhesion characteristics of oxygenated sickle and healthy red blood cells

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This experimental study shows enhanced magnetic separation of sickle red blood cells, indicating potential for improved transfusion methods.

This research aims to explore magnetic separation methods for enhancing the removal of sickle red blood cells.
Whole blood collected from healthy and sickle cell donors
RBCs isolated using phosphate buffered saline and centrifugation
Processed through a magnetically-activated cell separation column and analyzed for capture ratio using a Coulter Counter
Sickle cell disease samples exhibited higher capture ratios compared to healthy samples during magnetic processing
Mean magnetophoretic mobility for sickle RBCs was consistently negative, indicating diamagnetic behavior.
Healthy RBCs showed significant differences in magnetophoretic behavior, potentially due to the presence of methemoglobin.

Iyer et al. (2025) studied this question.

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This experimental study shows enhanced magnetic separation of sickle red blood cells, indicating potential for improved transfusion methods.