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This research aims to evaluate the use of magnetophoresis to differentiate sickle red blood cells from healthy ones based on oxygen levels.

February 21, 2026ACS Measurement Science AuOpen Access

Dissolved Oxygen-Dependent Magnetophoresis of Sickle Red Blood Cells and Proof-of-Concept Separation Using a Magnetic Column

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This research demonstrates magnetophoresis efficacy in isolating sickle red blood cells from healthy ones, suggesting new diagnostic avenues.

This research aims to evaluate the use of magnetophoresis to differentiate sickle red blood cells from healthy ones based on oxygen levels.
Measured single-cell magnetophoretic mobilities using cell tracking velocimetry under controlled oxygen conditions.
Conducted experiments with 4 healthy and 5 sickle cell disease samples.
Performed preliminary separations using a Miltenyi LS column under air-saturated conditions.
Quantified cell fractions with a Coulter Counter and cell tracking velocimetry.
Significant differences in magnetophoretic mobility between sickle and healthy red blood cells at low oxygen levels.
Magnetophoretic mobility reflects the oxygen-hemoglobin equilibrium.
Suggests potential for using magnetophoresis in sickle cell diagnostics and research.

Strayer et al. (2026) studied this question.

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This research demonstrates magnetophoresis efficacy in isolating sickle red blood cells from healthy ones, suggesting new diagnostic avenues.