What question did this study set out to answer?

To explore fast-field-cycling NMR relaxometry as a method for differentiating hemoglobin S from hemoglobin A in sickle cell disease.

April 12, 2026Applied Magnetic ResonanceOpen Access

Exploiting Fast-Field-Cycling NMR Relaxometry to Differentiate Sickle Cell Hemoglobin from Hemoglobin A

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Authors

KBKirsten BuniakUniversity of Surrey MGManuel Arsenio Lores GuevaraUniversidad de Oriente RKRémi KogonUniversity of Surrey

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Implication

Demonstrates the ability of fast-field-cycling NMR relaxometry to distinguish sickle cell hemoglobin from healthy hemoglobin, suggesting a potential diagnostic tool for sickle cell disease.

Key Points

To explore fast-field-cycling NMR relaxometry as a method for differentiating hemoglobin S from hemoglobin A in sickle cell disease.
Utilized five blood samples from healthy individuals and two from sickle cell disease patients.
Measured frequency-dependent relaxation rates using fast-field-cycling NMR.
Analyzed NMR dispersion profiles using the 3-Tau Model to extract fit parameters.
Successfully distinguished between hemoglobin S and hemoglobin A using NMRD profiles.
Found that surface water dynamic time constants for HbS are approximately half that of HbA.
Linked bulk water dynamic correlation time to HbS polymerization and viscosity.

Cite This Study

Buniak et al. (2026) studied this question.

synapsesocial.com/papers/69db36a04fe01fead37c4ac7 https://doi.org/10.1007/s00723-026-01837-9

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Implication

Demonstrates the ability of fast-field-cycling NMR relaxometry to distinguish sickle cell hemoglobin from healthy hemoglobin, suggesting a potential diagnostic tool for sickle cell disease.

Exploiting Fast-Field-Cycling NMR Relaxometry to Differentiate Sickle Cell Hemoglobin from Hemoglobin A

Discussion

Member takes

Implication

Key Points

Cite This Study

Exploiting Fast-Field-Cycling NMR Relaxometry to Differentiate Sickle Cell Hemoglobin from Hemoglobin A

Discussion

Member takes

Implication

Key Points

Cite This Study

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