What type of study is this?

This is a Cohort Study study (also classified as: Pre-Registered Trial).

What question did this study set out to answer?

To evaluate the efficacy of droplet digital PCR for measurable residual disease detection and relapse prediction in KMT2A-rearranged leukemia after transplantation.

December 8, 2025BloodOpen Access

Droplet digital PCR improves measurable residual disease detection and predicts relapse in KMT2A-rearranged leukemia after allogeneic hematopoietic stem cell transplantation: A prospective study

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Authors

XMXiao‐Dong MoPeking University YWYu WangAffiliated Hospital of Liaoning University of Traditional Chinese Medicine

Discussion

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Implication

Prospective trial shows droplet digital PCR improves MRD monitoring and predicts relapse in KMT2A-rearranged leukemia, indicating better patient outcomes.

Key Points

To evaluate the efficacy of droplet digital PCR for measurable residual disease detection and relapse prediction in KMT2A-rearranged leukemia after transplantation.
Conducted a prospective trial enrolling patients with KMT2A-rearranged acute leukemia undergoing allo-HSCT.
Performed serial MRD monitoring using both RT-qPCR and ddPCR targeting KMT2A fusion transcripts post-HSCT.
Categorized patients based on MRD results into three groups: double-negative, discordant, and double-positive.
110 patients (69.6%) were classified as discordant based on MRD results.
Dis patients showed worse outcomes compared to double-negative with a 2-year recurrence rate of 7.69%.
Pre-HSCT KMT2A MRD positivity was independently associated with higher relapse rates.

Cite This Study

Mo et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e56b https://doi.org/10.1182/blood-2025-3518

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Implication

Prospective trial shows droplet digital PCR improves MRD monitoring and predicts relapse in KMT2A-rearranged leukemia, indicating better patient outcomes.

Droplet digital PCR improves measurable residual disease detection and predicts relapse in KMT2A-rearranged leukemia after allogeneic hematopoietic stem cell transplantation: A prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Droplet digital PCR improves measurable residual disease detection and predicts relapse in KMT2A-rearranged leukemia after allogeneic hematopoietic stem cell transplantation: A prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

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